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Cellular Housekeeper, And Potential Target Of Obesity Drugs

August 4, 2010 – 11:21 am

Scientists from the U.S. Department of Energy’s Lawrence Berkeley National Laboratory have obtained the closest look yet of how a gargantuan molecular machine breaks down unwanted proteins in cells, a critical housekeeping chore that helps prevent diseases such as cancer. They pieced together the molecular-scale changes the machine undergoes as it springs into action, ready to snip apart a protein. Their work provides valuable clues as to how the molecular machine, a giant enzyme called tripeptidyl peptidase II, keeps cells tidy and disease free…

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