Effect Of The Specific Src Family Kinase Inhibitor Saracatinib On Osteolytic Lesions Using The PC-3 Bone Model
August 3, 2010 – 5:21 amUroToday.com – One mechanism of castration-resistant prostate cancer growth and progression is by activation of the androgen receptor via the non-receptor tyrosine kinase, Src kinase. Src is activated by growth factors and neuropeptides that are upregulated by androgen deprivation and castration-resistant progression. Activated Src is known to contribute to castration-resistant prostate cancer (CRPC) growth and metastasis. It is also known that osteoclasts express Src and activation in osteoclasts promotes cell proliferation…
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Tags: Androgen Receptor, Bone, Castration, Cell Proliferation, Effect, Express, Family, Growth Factors, Inhibitor, Kinase, Lesions, Model, Model Photos, Neuropeptides, Osteoclasts, Osteolytic, Osteolytic Lesions, Pc 3, Prostate, Prostate Cancer, Prostate Cancer Growth, Receptor Tyrosine Kinase, Saracatinib, Specific, Src Family, Using
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