Keeping Stem Cells From Changing Fates
September 10, 2010 – 1:21 pmJohns Hopkins researchers have determined why certain stem cells are able to stay stem cells. The report in the June 4 issue of Cell Stem Cell reveals that an enzyme that changes the way DNA is packaged in cells allows specific genes to be turned on and off, thereby preventing a stem cell from becoming another cell type. Each cell has to fit in 6 feet of highly organized and carefully packaged DNA. Some regions of the DNA are more tightly compacted than others and this structure is dynamic. There are specific enzymes that change how condensed the DNA is to help turn genes on and off…
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