Prostate Cancer Genes Associated With TMPRSS2-ERG Gene Fusion And Prognostic Of Biochemical Recurrence In Multiple Cohorts
March 22, 2010 – 11:21 amUroToday.com – Fusion of the promoter/enhancer region of the androgen-responsive prostate specific serine protease 2-encoding gene, TMPRSS2 to the ETS variant 1 gene (ETV1) occurs uniquely in prostate cancer (CaP). Approximately 40-50% of CaP cases demonstrate a gene fusion. The most common fusion variant is a recombination between exon 1 of TMPRSS2 and exon 4 of ERG, designated T1/E4. This fusion may account for up to 85% of reported fusions. A previous study isolated RNA from 165 patients’ radical prostatectomy specimens and 81 (49%) were found to have a gene fusion…
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Tags: Associated, Biochemical, cancer, Cancer Genes, Cap, Cohorts, Ets, Etv1, Exon, Fusion, Gene, Gene Fusion, Genes, Multiple, Prognostic, Promoter, Prostate, Prostate Cancer, Prostatectomy, Radical Prostatectomy, Recombination, Recurrence, Rna, Serine Protease, Specimens, T1, TMPRSS2ERG
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